偏心回转式抛磨加工原理分析

介绍偏心回转式抛磨加工的基本原理，分析了这种基本加工原理下的惯性力，磨块与工件之间的作用力。通过改变辅具的结构形状，可以改变这些力的方向与磨块与工件间的作用方式，从而可完成对不同形状、尺寸、加工要求零件的高效去笔刺和光整加工。     

数学与真善美

本文探讨数学与真善美之间的关系，从而认为数学是真善美的统一，因而是构成数学美。     

Evolution of neoplastic cell lineages in Barrett oesophagus.

It has been hypothesized that neoplastic progression develops as a consequence of an acquired genetic instability and the subsequent evolution of clonal populations with accumulated genetic errors. Accordingly, human cancers and some premalignant lesions contain multiple genetic abnormalities not present in the normal tissues from which the neoplasms arose. Barrett oesophagus (BE) is a premalignant condition which predisposes to oesophageal adenocarcinoma (EA) that can be biopsied prospectively over time because endoscopic surveillance is recommended for early detection of cancer. In addition, oesophagectomy specimens frequently contain the premalignant epithelium from which the cancer arose. Neoplastic progression in BE is associated with alterations in TP53 (also known as p53) and CDKN2A (also known as p16) and non-random losses of heterozygosity (LOH). Aneuploid or increased 4N populations occur in more than 90-95% of EAs, arise in premalignant epithelium and predict progression. We have previously shown in small numbers of patients that disruption of TP53 and CDKN2A typically occurs before aneuploidy and cancer. Here, we determine the evolutionary relationships of non-random LOH, TP53 and CDKN2A mutations, CDKN2A CpG-island methylation and ploidy during neoplastic progression. Diploid cell progenitors with somatic genetic or epigenetic abnormalities in TP53 and CDKN2A were capable of clonal expansion, spreading to large regions of oesophageal mucosa. The subsequent evolution of neoplastic progeny frequently involved bifurcations and LOH at 5q, 13q and 18q that occurred in no obligate order relative to each other, DNA-content aneuploidy or cancer. Our results indicate that clonal evolution is more complex than predicted by linear models.     

南宁第三系湖相沉积泥岩特性试验研究

在静载荷试验基础上,进行多项室内试验,对南宁泥岩的崩解、膨胀性、吸力特性、强度特性、固结特性进行了探讨.     

配价语法中的补足语

围绕英语形容词的补足语展开了论述.作者探讨了配价理论中的补足语和说明语的区别,并列出了配价语法中几种补足语的形式.文章还就补足语的进一步划分以及补足语和说明语的区分方法等问题作了论述.     

The nuclear envelope: emerging roles in development and disease

The chromosomes of eukaryotic cells are separated from the cytoplasm by the nuclear envelope. The nuclear envelope includes two riveted membranes, plus embedded pore complexes that mediate nuclear import and export. In this sense, the nuclear envelope is truly a border zone. However, the envelope also links directly to chromosomes, and anchors two major infrastructures--the nuclear lamina and Tpr filaments--to the nuclear perimeter. Proteins of the nuclear envelope mediate a variety of fundamental activities, including DNA replication, gene expression and silencing, chromatin organization, cell division, apoptosis, sperm nuclear remodeling, the behavior of pronuclei, cell fate determination, nuclear migration and cell polarity. Furthermore, mutations in nuclear lamins and lamin-binding proteins cause tissue-specific inherited diseases. This special issue of Cell and Molecular Life Sciences is devoted to recent major advances in the characterization of nuclear envelope proteins and their roles. We offer here an overview of the topics covered in this issue of CMLS, and also discuss the emerging recognition that the nuclear envelope is an organelle critical for a wide range of genetic and developmental activity in multicellular organisms.     

基于词二元接续的中文文本自动查错研究

运用语料库语言统计方法对中文文中自动查错的有关问题进行探讨，运用词二元接续关系进行查错，主要依据词二元同现概率，互信息，t-测试差，其中，t-测试差是首次被应用于查错。     

门控伺服式交流稳压器的设计

分析了目前市场上常见的各类稳压器的工作原理及存在的缺陷,并对已获得国家实用新型专利的门控伺服式交流稳压器的设计过程及工作原理和特点进行了技术、经济分析.     

冲击式采煤机传动系统动态仿真结果分析

建立了冲击式采煤机传动系统动态分析模型，编制了仿真软件，重点分析了该软件运行结果。该软件的编制给冲击式采煤机的设计和优化提供了方便、快捷的手段。